If the patient can provide history, there are several important pieces of information to obtain.

Theoretically, this may occur in children or patients with compromised skin, such as due to burns or psoriasis. However, the serum concentrations do not reach toxic levels.

Elimination is further delayed in patients with underlying renal and liver disease.ĭermal salicylate preparations have been shown to reach the bloodstream.

With increased salicylate levels, these pathways become saturated resulting in zero order elimination. The liver metabolizes salicylates by first-order elimination, and the inactive metabolites are then excreted in the urine. Absorption continues in the small intestine. Aspirin can cause pyloric sphincter spasms, which increases the amount of time in the stomach allowing for more absorption. Aspirin has the propensity to form bezoars which will delay absorption. Food in the stomach at the time of ingestion can delay absorption. The formulation of the salicylate (extended vs. A variety of factors can affect absorption. The ionization constant of aspirin is 3, which makes it is more readily absorbed in acidic environments such as the stomach.

Antidote for paracetamol poisoning